NIH R29 FIRST award
In vivo analyses of hypertrophy mediated gene activation
PI: Michael E. Ritchie, MD

Veterans Administration Merit Review Award
In vivo analyses of hypertrophy mediated gene activation
PI: Michael E. Ritchie, MD

American Heart Association- Ohio Affiliate, Grant in aid
Signal transduction of hypertrophy in vivo
PI: Michael E. Ritchie, MD

Ritchie, M.E., Trask, R.V., Fontanet, H.L., and Billadello, J.J.: Multiple positive and negative elements regulate human brain creatine gene expression. Nucleic Acids Research 19:6231-6240, 1991.

Trask, R.V., Koster, J.C., Ritchie, M.E., and Billadello, J.J.: The human M creatine kinase gene enhancer contains multiple functional interacting domains. Nucleic Acids Research 20:2313-2320, 1992.

Ritchie, M.E., Waggoner, A.D., Davila-Roman, V.G., Barzilai, B., Trulock, E.P., and Eisenberg, P.R.: Echocardiography characterization of the improvement in right ventricular, function in patient with severe pulmonary hypertension after single lung transplant. J. A<. Coli. Cardiology 22:1170-1174, 1993.

Ritchie, M.E., Davila- Roman, V.g., and Barzilai, B.: Bi-plane transesophageal echocardiography identifies dynamic right ventricular outflow tract obstruction following single lung transplant and ventricular septal defect repair. Chest 105:610-611, 1994.

D’Angelo, D.O., Davis, M.G., Houser W.A., Eubak, J.J., Ritchie, M.E., and Dorn, G.W.: Characterization of the 5′ end of the human thromboxane receptor gene: Organizational analysis and mapping of protein kinase C responsive elements regulating expression in platelets. Circ. Res. 77:466-474, 1995.

Ritchie, M.E.: Characterization of human B creatine kinase gene expression in the heart in vitro and in vivo. J. Bile. Chern. 271:25485-25491, 1996.

Ritchie, M.E.: Human B creatine kinase gene expression in C2C12 cells is regulated by protein interactions involving the first exon. Biochem. Biophys. Research Comm. 223:765-769, 1996.

Kim, L., Stevens, A., Fu, J., Collins, M., and Ritchie, M.E.: bFGF induces BCK promoter driven expression in muscle via increased binding of a nuclear protein. Amer. J. Phys. 273:c223-c229, 1997.

Ritchie, M.E.: Ergonovine testing directed therapy and long term outcome of sudden death survivors with no apparent heart disease. Cardiology, 89: 76-78, 1998.

Singh, B.K., Green, A.L., and Ritchie, M.E.: Pseudo-pseudoaneurysm of the left ventricle. Cardiology, 89:159-161, 1998,

Ritchie, M.E.: Use of transesophageal echocardiography to detect unsuspected massive pulmonary emboli. J. Amer. Soc. Echocardiogr. 11:751-4, 1998.

Ritchie, M.E.: NfkB is selectively and markedly elevated in humans with unstable angina. Circulation 98:1707-1719, 1998.

Ritchie, M.E., Kim, L., Lee, T., Fu, J., and Collins, M.: Transcriptional induction of brain creatine kinase in acute pressure overload hypertrophy in vivo is via increased binding of a 60 kD nuclear protein with a 33 base pair enhancer. Circ. Res.

Kim, L., Lee, T., Fu, J., and Ritchie, M.E.: Characterization on MAP kinase, protein kinase C isoform, and gene activation and the influence of ACE inhibition in pressure overload hypertrophy in vivo. Amer. J. Phys.

Lee, T., Kim, L., Fu, J., and Ritchie, M.E.: Inhibition of gene expression by angiotension converting enzyme inhibitors in pressure overload hypertrophy in vivo is not via MAP kinase dependent pathway. Amer. J.Phys.

Lauer, J., Ritchie, M.E.: Three separate coronary artery ostia arising from the right coronary cusp: A case report. Cath. Cardiovas. lnterv.

Dillon, W., Hadian, D., Ritchie, M.E.: Refractory no-flow successfully treated with local infusion of high dose adenosine and verapamil. Cath. Cardiova. lnterv.

Ritchie, M.E.: Characterization of STAT3 activation in pressure overload hypertrophy in vivo (In preparation).

Ritchie, M.E.: Circulating NFkB levels do not correlate with rejection in human heart transplant patients (In preparation).

Ritchie, M.E.: Level of NFkB activation in circulation correlates with subsequent coronary artery events in humans: its utility as a marker for therapy effectiveness (in preparation).

Ritchie, M.E.: Green fluorescent protein (GFP) is a marker of fibroblasts undergoing myogenic conversion (in preparation).

Sturdevant, L.K., Fleten, R., Ritchie, M.E.: ACE inhibitor- mediated activation of apoptosis during regression of established hypertrophy (in preparation).

Brandstetter, A., Sturdeant, L.K., Ritchie, M.E.: Characterization of the changes in gene expression during ACE- mediated regression of pressure overload induced left ventricular hypertrophy (In preparation).

Collins, T., Lauer, J., Brandstetter, A., Ritchie, M.E.: Signaling events during ACE inhibitor mediated regression of established left ventricular hypertrophy (in preparation).

Strudevant, L.K., Brandstetter, A., Ritchie, M.E.: Apoptosis induced during pressure overload mediated hypertrophy in adult rat hearts can be abrogated y pretreatment with ACE inhibitors (in preparation).

Dillion, W., Dillion, J., Daniel, G., Ritchie, M.E.: A method to reduce atherosclerotic debris during precutaneous coronary intervention (in preparation).

Dillion, W., Daniel, G., Ritchie, M.E.: Abciximab can achieve therapeutic levels of Gil billa receptor blockade at doses less than full (in preparation).

Gupta, R., Daniel, G., Ritchie, M.E.: Prospective serial determination of systemic NFkB activation accurately predicts the acuity of clinical cardiovascular event (in preparation).

Daniel, G., Gupta, R., Dillion, W., Ritchie, M.E.: Differing effects of HMG-CoA reductase inhibitors and Non-acetylated salicylic acid on CRP, LDL-cholesterol, and NFkB levels in humans (in preparation).

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